Isabel Gainza-Apraiz, Servicio de Dermatología, Hospital Universitario Basurto, Bilbao, España
Ane Lobato-Izagirre, Servicio de Dermatología, Hospital Universitario Basurto, Bilbao, España
Nerea González-Romero, Servicio de Dermatología, Hospital Universitario Basurto, Bilbao, España
Mikel Meruelo-Ruano, Servicio de Dermatología, Hospital Universitario Basurto, Bilbao, España
Mireya Lázaro-Serrano, Servicio de Dermatología, Hospital Universitario Araba, Vitoria-Gasteiz, País Vasco. España
Rosa Mª Izu-Belloso, Servicio de Dermatología, Hospital Universitario Basurto, Bilbao, España
Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects the folliculosebaceous unit in large intertriginous body areas. Longstanding inflammation might lead to the development of a squamous cell carcinoma arising in HS lesions, which is more likely to occur in males and at the gluteal or perineal sites. Case report: A 57-year-old man with an over 30-year history of severe HS (Hurley III) involving the buttocks and refractory to a wide variety of treatments developed a squamous cell carcinoma over HS lesions. He presented large locoregional lymphadenopathies at diagnosis. Surgery and radiotherapy were dismissed and he was treated with palliative chemotherapy. Discussion: Human papillomavirus (HPV) and other cofactors seem to be involved in the malignant transformation of the lesions. Due to the common delayed diagnosis and its high metastatic ability, prognosis is poor and mortality rates high. Conclusion: Areas of non-healing wounds should be cautiously observed and multiple deep biopsies carried out in patients suffering from longstanding and resistant HS, especially if they involve the buttocks or perineum, in order to detect the development of a squamous cell carcinoma arising in HS lesions at an early stage.
Keywords: Hidradenitis suppurativa. Malignant tumors. Squamous cell carcinoma.
