Sónia Santos, Internal Medicine Department, Centro Hospitalar de Leiria, Leiria, Portugal
Katarina Kieselová, Dermatology Department. Centro Hospitalar de Leiria, Leiria, Portugal
António Antunes, Internal Medicine Department;, Centro Hospitalar de Leiria, Leiria, Portugal
Martinha Henrique, Dermatology Department. Centro Hospitalar de Leiria, Leiria, Portugal
Sweet’s syndrome (Acute febrile neutrophilic dermatosis) is a rare dermatosis that may be classified in three different groups: classical (or idiopathic), malignancy-associated or drug induced. The drug-induced disease most commonly occurs in patients who have been treated with granulocyte-colony stimulating factor, although other medications may also be associated. Sweet’s syndrome is characterized by tender erythematous skin lesions (papules, nodules, plaques) together with fever, neutrophilia and a diffuse infiltrate consisting predominantly of mature neutrophils that are typically located in the upper dermis. We report a case of a 57-year-old male that initiated azathioprine two weeks before presenting scattered skin lesions associated with fever. The diagnosis of Sweet’s syndrome was made. The corticoid dose was increased and azathioprine was discontinued. The patient improved within a week and did not have any relapse.
Keywords: Azathioprine. Drug reaction. Febrile neutrophilic dermatosis. Sweet’s syndrome.